Education
Experience
Latest publications
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scReady - an automated and accessible pipeline for single-cell RNA-Seq preprocessing: Empowering novice bioinformaticians [version 1; peer review: 1 approved with reservations]
Authors: Domenico Somma, William Haese-Hill, Fiona Achcar, Yiyi Cheng, Scott Arkison, Thomas D Otto
Wellcome Open Research • 2026-01-19
Single-cell RNA sequencing is a powerful technology that lets researchers see which genes are active in individual cells, and its use is growing rapidly. Between generating the raw data in the lab and...
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RNAcare: integrating clinical data with transcriptomic evidence using rheumatoid arthritis as a case study
Authors: Mingcan Tang, William Haese-Hill, Fraser Morton, Carl Goodyear, Duncan Porter, Stefan Siebert, Thomas D Otto
BMC Medical Genomics • 2025-05-21
Gene expression analysis is a crucial tool for uncovering the biological mechanisms that underlie differences between patient subgroups, offering insights that can inform clinical decisions. However, ...
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paraCell: a novel software tool for the interactive analysis and visualization of standard and dual host–parasite single-cell RNA-seq data
Authors: Edward Agboraw, William Haese-Hill, Franziska Hentzschel, Emma Briggs, Dana Aghabi, Anna Heawood, Clare R Harding, Brian Shiels, Kathryn Crouch, Domenico Somma, Thomas D Otto
Nucleic Acids Research • 2025-02-28
Advances in sequencing technology have led to a dramatic increase in the number of single-cell transcriptomic datasets. In the field of parasitology, these datasets typically describe the gene express...
Skills
Python
Django, NumPy, Pandas, Scanpy
TypeScript
React
R
Shiny, Seurat, tidyverse
Linux
Bash, nginx
Databases
SQL, NoSQL
Version control
git, GitHub